A New Role for Cyclic Phosphatidic Acid as a PPAR gamma Antagonist

作者：Oishi Tanaka Yumiko; Glass Christopher K^*

来源：Cell Metabolism, 2010, 12(3): 207-208.

DOI：10.1016/j.cmet.2010.08.010

A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPAR gamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2. This endogenous CPA regulates PPAR gamma functions required for adipogenesis, glucose homeostasis, and vascular wall biology.

• 出版日期2010-9-8