A novel indigoid anti-tuberculosis agent

作者：Klein Larry L^*; Petukhova Valentina; Wan Baojie; Wang Yuehong; Santasiero Bernard D; Lankin David C; Pauli Guido F; Franzblau Scott G

来源：Bioorganic & Medicinal Chemistry Letters, 2014, 24(1): 268-270.

DOI：10.1016/j.bmcl.2013.11.024

• Anti-tuberculosis
• Indigoid
• X-ray

The structure of a novel indigoid component was characterized by X-ray crystallography. This compound exhibited excellent anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv in whole cell culture showing a submicromolar minimum inhibitory concentration (MIC). A synthesis of this molecule was designed and carried out to produce sufficient material for further testing. The in vitro profile, structure, and first synthesis of this indigoid component is reported.

• 出版日期2014-1-1