Association between pulse wave velocity and hot flashes/sweats in middle-aged women

作者：Yang, Ruwei; Zhou, Yang; Li, Changbin; Tao, Minfang^*

来源：Scientific Reports, 2017, 7(1): 13854.

DOI：10.1038/s41598-017-13395-z

• MENOPAUSE RATING-SCALE
• QUALITY-OF-LIFE
• POSTMENOPAUSAL WOMEN
• RISK-FACTORS
• CARDIOVASCULAR-DISEASE
• ARTERIAL STIFFNESS
• METABOLIC SYNDROME
• SYMPTOMS
• HEALTH
• POPULATION

As women age and go through menopause, they suffer a higher incidence of cardiovascular morbidity and mortality. Previous studies have shown that a relationship exists between hot flashes/sweats and an increased risk of cardiovascular disease. However, the association between hot flashes/sweats and arterial stiffness is unclear. We aim to explore the relationship between hot flashes/sweats and arterial stiffness using the modified Kupperman index (KMI) questionnaire and measure the brachial-ankle pulse wave velocity (baPWV). The prevalence of hot flashes in our research was reported to be 41.77%. There was a statistically significant difference between the mean baPWV among groups that experienced different severities of hot flashes/sweats according to one-way ANOVA test (p < 0.001). The baPWV values were positively associated with the severity of hot flashes/sweats based on linear regression after adjusting for established cardiovascular confounders (95% CI: (5.86, 43.23), p = 0.01). To the best of our knowledge, this study is the first investigation to propose that baPWV may serve both as an objective index for evaluating the severity of hot flashes/sweats and as a predictor of arterial stiffness beyond Cardiac Vascular Disease (CVD) risk factors in middle-aged women.

• 出版日期2017-10-23
• 单位上海交通大学