A Comparative Study of Two Novel Nanosized Radiolabeled Analogues of Methionine for SPECT Tumor Imaging

作者：Khosroshahi A G; Amanlou M; Sabzevari O; Daha F J; Aghasadeghi M R; Ghorbani M; Ardestani M S; Alavidjeh M S; Sadat S M; Pouriayevali M H; Mousavi L; Ebrahimi S E S^*

来源：Current Medicinal Chemistry, 2013, 20(1): 123-133.

• Tumor cells
• nanosized
• methionine
• DTPA
• dendrimer G(2)
• SPECT

It has been reported that most tumor cells show an increased uptake of variety of amino acids specially methionine when compared with normal cells and amino acid transport is generally increased in malignant transformation. Based on the evidences, two novel nanosized analogues of methionine (Anionic Linear Globular Dendrimer G(2), a biodigredabale anionic linear globular-Methionin, and DTPA-Methionine(1) conjugates) were synthesized and labeled with Tc-99m and used in tumor imaging/ therapy in vitro and in vivo. The results showed marked tumor SPECT molecular imaging liabilities for both compounds but with a better performance by administration of 99mTc-Dendrimer G(2)-Methionin. The results also showed a good anticancer activity for Tc-99m-DTPA-Methionine. Based on the present study Tc-99m-Dendrimer G(2)-Methionin or 99mTc-DTPA-(Methionine)(1) have potentials to be used in tumor molecular imaging as well as cancer therapy in future.

• 出版日期2013-1