Approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines

作者：Subota Andrii I; Artamonov Oleksiy S; Gorlova Alina; Volochnyuk Dmitriy M; Grygorenko Oleksandr O^*

来源：Tetrahedron Letters, 2017, 58(20): 1989-1991.

DOI：10.1016/j.tetlet.2017.04.030

• Nitrogen heterocycles
• Fused azepanes
• Pyridine
• Aza-Wittig reaction
• Lead-oriented synthesis

An approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-clazepines via the cyclization of 1-(2-(3-azidopropyl)pyridin-3-yl)alkanones under Staudinger aza-Wittig reaction conditions is described. The overall reaction sequence includes eight steps and allows for the preparation of gram quantities of the title products. In some cases, the formation of 5,7,8,9-tetrahydrooxepino[4,3-b]pyridine derivatives was observed.

• 出版日期2017-5-17