A novel coumarin based molecular switch for the sequential detection of Al3+ and F-: Application in lung cancer live cell imaging and construction of logic gate

作者：Sarkar Deblina; Ghosh Paramita; Gharami Saswati; Mondal Tapan Kumar^*; Murmu Nabendu^*

来源：Sensors and Actuators B: Chemical , 2017, 242: 338-346.

DOI：10.1016/j.snb.2016.11.059

• Coumarin based sequential chemosensor
• for Al3+ and F-
• Spectral characterization
• A549 lung cancer cell line
• Live cell imaging
• INHIBIT logic gate
• DFT calculation

A highly sensitive and selective coumarin based chemosensor H2L for the efficient detection of Al3+ has been developed. The synthesized chemosensor H2L is efficient in detecting Al3+ over other metal ions which are commonly obtained in various physiological and environmental samples. H2L shows fluorescence 'turn-on' response at 610nm in presence of Al3+, without the interference of other metal ions. The resulting H2L-Al3+ complex behave as a sequential chemosensor for F-, by showing quenching of emission intensity upon addition of F- to it. This quenching of emission intensity is only specific for F- and is not hampered due to the presence of other anions that commonly coexist with F- in various environmental solutions. Theoretical calculations using DFT/B3LYP method has been used to get insight into the sensing mechanism as well as electronic structure of the synthesized chemosensor H2L. H2L is efficient in detecting Al3+ in the intracellular region of human A549 cell and also exhibits an INHIBIT logic gate with Al3+ and F- as chemical inputs by monitoring the emission mode at 610nm.

• 出版日期2017-4