Dietary fat intake and endometrial cancer risk: dose-response meta-analysis of epidemiological studies

作者：Jiang, Luo; Hou, Rui; Gong, Ting-Ting; Wu, Qi-Jun^*

来源：Scientific Reports, 2015, 5(1): 16693.

DOI：10.1038/srep16693

• ORAL-CONTRACEPTIVE USE
• NUTRITIONAL FACTORS
• COLORECTAL-CANCER
• ASSOCIATION
• CONSUMPTION
• VEGETABLES
• REDUCTION
• NUTRIENTS
• DISEASE
• ENERGY

Epidemiological studies have provided controversial evidence of the association between dietary fat intake and endometrial cancer (EC) risk. To address this inconsistency, we conducted this doseresponse meta-analysis by total dietary fat intake, based on epidemiological studies published up to the end of June 2015 identified from PubMed, EMBASE and Web of Science. Two authors (RH and Q-JW) independently performed the eligibility evaluation and data extraction. All differences were resolved by discussion with the third investigator (LJ). Random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Overall, the search yielded 16 studies (6 cohort and 10 case-control studies) that involved a total of 7556 EC cases and 563,781 non-cases. The summary RR for EC for each 30g/day increment intake was 0.98 (95% CI = 0.95-1.001; I-2 = 0%; n = 11) for total dietary fat. Non-significant results were observed in plant-based fat (summary RR = 1.05, 95% CI = 0.94-1.18; I-2 = 0%; n = 5) and animal-based fat (summary RR = 1.17, 95% CI = 0.92-1.36; I-2 = 85.0%; n = 6). Additionally, the null associations were observed in almost all the subgroup and sensitivity analyses. In conclusion, findings of the present meta-analysis suggested a lack of association between total dietary fat intake and EC risk. Further studies, especially prospective designed studies are warranted to confirm our findings.

• 出版日期2015-11-16
• 单位中国医科大学