Advances in atopic dermatitis in 2015

作者：Nomura Takashi; Kabashima Kenji

来源：Journal of Allergy and Clinical Immunology, 2016, 138(6): 1548-1555.

DOI：10.1016/j.jaci.2016.10.004

• Atopic dermatitis
• filaggrin
• biologics
• cytokines
• chemokines
• thymic stromal lymphopoietin
• chemoattractant receptor-homologous molecule expressed on T(H)2 cells
• petrolatum
• ultraviolet B
• sirtuin 1
• aryl hydrocarbon receptor
• Janus kinase
• signal transducer and activator of transcription 3
• extracellular
• signal-regulated kinase
• pathogenic effector T(H)2 T(H)1T(H)2 T(H)17 T(H)22
• transepidermal water loss
• adiposity
• JTE-052

This review aims to highlight recently published articles on atopic dermatitis (AD). Updated are the insights into epidemiology, pathology, diagnostics, and therapy. Epidemiologic studies have revealed a positive correlation between AD and systemic conditions, such as rheumatoid arthritis, inflammatory bowel disease, and neonatal adiposity. Pathologic findings highlight the involvement of novel barrier factors (desmoplakin and claudin), novel immune cell subsets (pathogenic effector T(H)2 cells and group 2 innate lymphoid cells), and differential skewing of helper T cells (eg, T(H)17 dominance in Asians with AD). As diagnostics, noninvasive examinations of the transepidermal water loss of neonates, the density of epidermal Staphylococcus species, and the gut flora might prognosticate the onset of AD. As for therapy, various methods are proposed, including conventional (petrolatum and UV) and molecule-oriented regimens targeting Janus kinase, signal transducer and activator of transcription 3, extracellular signal-regulated kinase, sirtuin 1, or aryl hydrocarbon receptor.

• 出版日期2016-12
• 单位河北医科大学