Antibacterial and osteogenic stem cell differentiation properties of photoinduced TiO2 nanoparticle-decorated TiO2 nanotubes

作者：Liu Wenwen; Su Penglei; Chen Su^*; Wang Na; Wang Jinshu; Liu Yiran; Ma Yuanping; Li Hongyi; Zhang Zhenting; Webster Thomas J

来源：Nanomedicine, 2015, 10(5): 713-723.

DOI：10.2217/NNM.14.183

• antibacterial effect
• photocatalysis
• stem cells
• TiO2 nanoparticles
• titania nanotubes

Aim: To improve the antibacterial and mammalian cell compatibility properties of titania nanotubes (TNTs) anodized into titanium (Ti). Materials & methods: 3-8-nm TiO2 nanoparticles were decorated on the surface and inside TNT (TNT-TiO2) through a hydrothermal method. After UV light treatment, two types of oral bacteria and stem cells were cultured on the samples to determine antibacterial and compatibility properties. Results: TiO2 nanoparticles increased the surface area and photocatalysis of TNTs. Based on the photocatalysis effect and prolonged photo-induced wettability, the numbers of Streptococcus mutans and Porphyromonas gingivalis were lower on the surface of TNT-TiO2 than pure Ti and TNTs after the first 7 days. Specifically, for S. mutans, the glycosytransferase (gtf) genes were downregulated 0.1-0.2-fold on TNT-TiO2. Due to the different topography and high surface energy of TNT-TiO2, stem cells also showed improved osteogenic functions on TNT-TiO2. Conclusion: In this study, we demonstrated for the first time improved antibacterial properties and, at the same time, greater stem cell osteogenic capacity when decorating TNTs with nanosized TiO2 particles, which may significantly improve orthopedic and dental implant efficacy.

• 出版日期2015
• 单位北京工业大学; 首都医科大学; 东北大学