Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit

作者：Stephen L J^*; Parker P; Kelly K; Wilson E A; Leach V; Brodie M J

来源：Acta Neurologica Scandinavica, 2011, 124(2): 142-145.

DOI：10.1111/j.1600-0404.2011.01507.x

• antiepileptic drugs
• epilepsy
• seizures

Aims - Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004. This audit assessed the response to adjunctive PGB in patients with uncontrolled seizures. Methods - PGB was titrated in 135 patients [ 73 men; 62 women, aged 18-76 (median 44 years) until one of the following occurred: >= 6 months' seizure freedom, >= 50% or < 50% seizure reduction over 6 months; PGB withdrawal because of adverse effects, lack of efficacy or both. Results - Of the 135 patients, 14 (10.4%) became seizure-free for 6 months (median PGB dose 300 mg/day; range 75-600 mg). A 50% seizure reduction occurred in 33 (24.4%) patients; 20 (14.8%) had < 50% reduction. PGB was withdrawn in 68 (50.4%) (40 adverse effects, seven lack of efficacy and 21 both). Commonest problems resulting in withdrawal were sedation (n = 18), weight gain (n = 14) and ataxia (n = 9). There was a positive correlation between increasing dose and weight gain (r = 0.42, P = 0.045). Conclusions - Add-on PGB benefited 50% of patients, but only 10% achieved 6 months' seizure freedom. Adverse effects, most commonly sedation, dose-related weight gain and ataxia, led to drug discontinuation by 45%. Prospective audits of novel AEDs are a useful adjunct to randomized, controlled trials in managing epilepsy.

• 出版日期2011-8