Association between lumican gene-1554 T/C polymorphism and high myopia in Asian population: a meta-analysis

作者：Liao Xuan; Yang Xu Bo; Liao Meng; Lan Chang Jun; Liu Long Qian^*

来源：International Journal of Ophthalmology, 2013, 6(5): 696-701.

DOI：10.3980/j.issn.2222-3959.2013.05.28

• lumican
• high myopia
• gene polymorphism
• meta-analysis

AIM: To investigate the association between lumican gene -1554 T/C polymorphism and high myopia susceptibility.
METHODS: We searched the published literature in the Medline, Embase, and CBM databases from inception to July 2013. A meta -analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.
RESLUTS: Seven case control studies with a total of 1 233 cases and 936 controls were included. A statistical significant association with high myopia was observed in the recessive model (TT vs CT+CC: OR =1.92; 95% CI = 1.14-3.23) and codominant model (TT vsCT: OR=1.81, 95%CI=1.19-2.75).
CONCLUSION: The present meta analysis suggested that lumican 1554 T/C polymorphism might be moderately associated with high myopia susceptibility. This conclusion warrants confirmation by further studies.

• 出版日期2013-10-18
• 单位四川大学