科研之友
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摘要
Background and AimPatients with achalasia typically have thicker lower esophageal sphincter muscles, which can affect the distensibility of the esophagogastric junction. We aimed to assess whether these muscular features, measured using high-frequency endoscopic ultrasound, affect treatment outcomes.
MethodsConsecutive adult patients with suspected achalasia were enrolled prospectively. They underwent a comprehensive diagnostic workup, including endoscopic ultrasound. The thickness of the lower esophageal sphincter, including the internal circular and outer longitudinal muscles, was measured using a 12-MHz ultrasonic miniprobe. Follow-up was performed at 1month and then at 6-month intervals, after treatment. Treatment response was defined as a reduction in Eckardt score to 3 or an improvement in the height of the timed barium esophagogram of 50%.
ResultsOf the 29 patients who received pneumatic dilatation, all but one (96.6%) exhibited a good short-term treatment response. At an average follow-up time of 18.5 (12-55.5)months, patients who had a mid-term recurrence after pneumatic dilatation had a significantly thicker outer longitudinal muscle (1.8 [1.5-1.8] vs 0.9 [0.8-1.7]mm, P=0.036), but not internal circular muscle (2.0 [1.9-2.5] vs 2.1 [1.2-2.7]mm, P=0.874) or total lower esophageal sphincter (3.7 [3.5-4.4] vs 3.6 [2.0-4.1] mm, P=0.362). Patients with an outer longitudinal muscle 1.3mm thick had a significantly lower mid-term remission rate than others (36.3% vs 100%, P=0.01).
ConclusionThickening of the outer longitudinal muscle at the lower esophageal sphincter is associated with poor mid-term treatment outcomes for achalasia patients treated with pneumatic dilatation.
- 出版日期2018-1
