A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats

作者：Wang Yuming; Guo Xuejun; Xie Jiabin; Hou Zhiguo; Li Yubo^*

来源：Molecules, 2015, 20(12): 21364-21372.

DOI：10.3390/molecules201219776

• GC-MS
• metabonomics
• rheumatoid arthritis
• Simiaowan

Simiaowan (SMW) is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis (RA). The aim of the present study is to determine novel biomarkers to increase the current understanding of RA mechanisms, as well as the underlying therapeutic mechanism of SMW, in RA-model rats. Plasma extracts from control, RA model, and SMW-treated rats were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). An orthogonal partial least-square discriminant analysis (OPLS-DA) model was created to detect metabolites that were expressed in significantly different amounts between the RA model and the control rats and investigate the therapeutic effect of SMW. Metabonomics may prove to be a valuable tool for determining the efficacy of complex traditional prescriptions.

• 出版日期2015-12
• 单位天津中医药大学