科研之友
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摘要
The leaves of persimmon (LP) have been used for centuries in China, Korea and Japan as a delicate, pleasant beverage and an effective herbal remedy. Phytochemical investigations of LP have resulted in the discovery of two new secoiridoid glucosides, named persimmonoid A and B (1-2), together with ten known ones. Antioxidant and neuroprotective assays of all compounds were carried out, and compounds (+)-medioresinol (5), (+)-pinoresinol (7), (+)-pinoresinol-beta-D-glucoside (10) and (-)-(7'S,8S,8'R)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy7',9-epoxylignan-9'-ol-7-one (12) were found to exhibit significant activity in the ABTS radical scavenging assay, while compounds (+)-syringaresinol (6), (+)-pinoresinol (7) and (+)isolariciresinol (11) displayed stronger activity than the positive control in the FRAP assay. In addition, some of these compounds showed statistically significant neuroprotective activities. The HPLC-QQQ-MS/MS method was successfully applied to quantify twelve compounds from LP and fruits of persimmon (FP). The bioactive studies supported LP potential for development as a new antioxidant and neuroprotective functional food.
