Unusual metal complex of cadinane sesquiterpene alkaloid and new neolignan glycosides from Alangium alpinum

作者：Ren, Jie; Xie, Yang-guo; Guo, Yi-gong; Zhu, Sheng-lan; Jin, Hui-zi^*; Zhang, Wei-dong^*

来源：Fitoterapia, 2018, 125: 18-23.

DOI：10.1016/j.fitote.2017.12.008

• Metal complex
• Cadinane sesquiterpene alkaloid
• Alangium alpinum

One unusual metal complex of cadinane sesquiterpene alkaloid (1), one new cadinane sesquiterpene alkaloid (2) and two new neolignan glycosides (3-4) along with six known cadinane sesquiterpene derivatives (5-10), nineteen known phenolic glycosides (11-29) were isolated from the aerial parts of Alangium alpinum. Structures of new crystals of metal complex were characterized by X-Ray diffraction and ICP-AES analysis. Other new compounds were elucidated by combined use and detailed analysis of HR-ESIMS, 1D and 2D NMR and CD spectroscopic method. In addition, all isolated compounds were tested for their inhibitory effects against TNF-alpha induced NF-kappa B activation in Hela cells and NO production in RAW 264.7 macrophages.

• 出版日期2018-3
• 单位上海大学; 上海交通大学