Anti-Mullerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age

作者：Sahmay Sezai; Oncul Mahmut^*; Tuten Abdullah; Tok Abdullah; Acikgoz Abdullah Serdar; Cepni Ismail

来源：Journal of Assisted Reproduction and Genetics, 2014, 31(11): 1469-1474.

DOI：10.1007/s10815-014-0324-y

• Anti-Mullerian hormone
• Advanced reproductive age
• In Vitro Fertilization

To investigate whether serum anti-mullerian hormone (AMH), follicle stimulating hormone (FSH), or antral follicle count (AFC) are predictive for clinical pregnancy in women who underwent IVF cycles at the age of 35 and older %26lt;br%26gt;A total of 240 consecutive women who underwent IVF cycles at the age of 35 and older were enrolled in this crsoss- sectional study. Pregnant and nonpregnant women were compared. %26lt;br%26gt;The median AMH level of pregnant women was higher than non-pregnant women [3.20 (0.63-9.60) vs 1.15 (0.01-14.90) ng/ml, p %26lt; 0.001]. On logistic regression analysis, AMH was an independent predictor of clinical pregnancy rate (CPR) (OR 1.353; 95 % CI 1.141-1.605; P %26lt; 0.001). After controlling for the other independent variables (the number of retrieved oocytes, AFC and age), the significant association between AMH and clinical pregnancy rate remained strong (OR 1.677; 95 % CI 1.216-2.311; p = 0.002) on multivariate logistic regression analysis. %26lt;br%26gt;AMH is an effective measure of quantitative ovarian reserve and it can predict ovarian response to controlled stimulation for advanced age women. The CPR tends to increase as AMH increases.

• 出版日期2014-11