Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice

作者：Liu Wei; Shan Li Ping; Dong Xue Song; Liu Zhi^*

来源：International Journal of Clinical and Experimental Medicine, 2014, 7(10): 3392-3397.

• Paraquat
• poisoning
• acute lung injury
• Toll-like receptor 4
• inflammation

Objective: To investigate the possible relationship and mechanism of Toll-like receptor 4 (TLR4) and acute lung injury induced by paraquat (PQ) poisoning. Methods: Male wild type mice and male TLR4-knockout mice were used in this study. After paraquat treatment for 24 hours, mice were euthanized and pathology, TLR4 expression and pro-inflammatory cytokines were evaluated. Results: Wild type mice showed deteriorated lung injury, pathological damages and increased TLR4 expression and pulmonary TNF-alpha, IL-1 beta and NF-kappa B p65 levels after PQ treatment. TLR4-deficient mice were significantly resistant to paraquat-induced lung injury. Conclusion: TLR4 may be required as a mediator and may play an important role in acute lung injury induced by paraquat.

• 出版日期2014
• 单位中国医科大学