Anti-Vpr activities of heat shock protein 27

作者：Liang Dong; Benko Zsigmond; Agbottah Emmanuel; Bukrinsky Michael; Zhao Richard Y^*

来源：Molecular Medicine, 2007, 13(5-6): 229-239.

DOI：10.2119/2007-00004.Liang

HIV-1 Vpr plays a pivotal role in viral pathogenesis and is preferentially targeted by the host immune system. In this report, we demonstrate that a small heat shock protein, HSP27, exhibits Vpr-specific antiviral activity, as its expression is specifically responsive to vpr gene expression and increased levels of HSP27 inhibit Vpr-induced cell cycle G2 arrest and cell killing. We further show that overexpression of HSP27 reduces viral replication in T-lymphocytes in a Vpr-dependent manner. Mechanistically, Vpr triggers HSP27 expression through heat shock factor (HSF) 1, but inhibits prolonged expression of HSP27 under heat-shock conditions. Together, these data suggest a potential dynamic and antagonistic interaction between HIV-1 Vpr and a host cell HSP27, suggesting that HSP27 may contribute to cellular intrinsic immunity against HIV infection,

• 出版日期2007-6
• 单位西北大学