Aging, Atherosclerosis, and IGF-1

作者：Higashi Yusuke; Sukhanov Sergiy; Anwar Asif; Shai Shaw Yung; Delafontaine Patrice^*

来源：Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2012, 67(6): 626-639.

DOI：10.1093/gerona/gls102

• IGF-1
• Oxidant stress
• Aging
• Atherosclerosis
• Inflammation

Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features of atherosclerotic plaque stability in animal models. Potential mechanisms for this atheroprotective effect include IGF-1-induced reduction in oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction. Aging is associated with increased vascular oxidative stress and vascular disease, suggesting that IGF-1 may exert salutary effects on vascular aging processes. In this review, we will provide a comprehensive update on IGF-1%26apos;s ability to modulate vascular oxidative stress and to limit atherogenesis and the vascular complications of aging.

• 出版日期2012-6