Dose-related effect of urinary cotinine levels on pulmonary function among Korean women

作者：Kim K Y; Myong J P^*; Kim H R; Lee H E; Jang T W; Koo J W; Park C Y

来源：International Journal of Tuberculosis and Lung Disease, 2014, 18(5): 622-627.

DOI：10.5588/ijtld.13.0677

• biomarker
• spirometry
• cotinine
• smoking
• KNHANES

SETTING: Country-wide general population in South Korea. %26lt;br%26gt;BACKGROUND: The dose-response relationship between smoking and pulmonary function in women may have been significantly over-estimated by studies that employed a self-reporting questionnaire. %26lt;br%26gt;OBJECTIVE: To evaluate whether this relationship was still observed among Korean women when smoking levels were determined by urinary cotinine measurements. %26lt;br%26gt;DESIGN: A total of 4584 Korean women from the spirometry data set of the Korean National Health and Nutrition Examination Surveys IV and V (2008-2010) were included. Analysis of covariance was performed to estimate the dose-related effect of urinary cotinine levels on pulmonary function after adjusting for covariates in this country-wide cross-sectional study. %26lt;br%26gt;RESULTS: Compared to urinary cotinine levels (cut-off 50 ng/ml), the false-positive rate of self-reported smoking was 53.2%. After the smokers were divided into deciles, the regression coefficients for percentage forced expiratory volume in 1 second (FEV1%) and percentage forced expiratory volume/forced volume capacity (FEV1/FVC) ratio (FEV1/FVC%) were -0.2903 and -0.2680 (%/decile), respectively (both P %26lt; 0.001). %26lt;br%26gt;CONCLUSION: It is necessary to use objective methods when determining the smoking status of Korean women. Even after reducing information bias, smoking affected pulmonary function in a dose-dependent manner.

• 出版日期2014-5