Associations Between XRCC1 Arg399Gln, Arg194Trp, and Arg280His Polymorphisms and Risk of Differentiated Thyroid Carcinoma: A Meta-analysis

作者：Du, Yang; Han, Li-Yuan; Li, Dan-Dan; Liu, Hui; Gao, Yan-Hui; Sun, Dian-Jun^*

来源：Asian Pacific Journal of Cancer Prevention, 2013, 14(9): 5483-5487.

DOI：10.7314/APJCP.2013.14.9.5483

• XRCC1
• Arg399Gln
• Arg194Trp
• Arg280His
• differentiated thyroid carcinoma
• meta-analysis

Background: Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory. Methods: We performed a meta-analysis in the present study using STATA 11.0 software to clarify any associations. Electronic literature databases and reference lists of relevant articles revealed a total of 10, 6 and 6 published studies for the Arg399Gln, Arg194Trp and Arg280His polymorphisms, respectively. Results: No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians. Conclusions: Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development.

• 出版日期2013
• 单位中国疾病预防控制中心; 哈尔滨医科大学; 宁波大学