A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly

作者：Fukuyama Yoshiko; Ikeda Yorihiko; Ohori Junichiro; Sugita Gen; Aso Kazuyoshi; Fujihashi Keiko; Briles David E; McGhee Jerry R; Fujihashi Kohtaro

来源：Immune Network, 2015, 15(1): 9-15.

DOI：10.4110/in.2015.15.1.9

• Mucosa
• Vaccination
• Aging
• Bacterial infection

Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective mucosal immunity against this pathogen in order to prevent pnuemocaccal infection. However, this is a very difficult task to elicit protective mucosal IgA antibody responses in older individuals. A combind nasal adjuvant consisting of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligonucleotide (CpG ODN) successfully enhanced S. pneumoniae-specific mucosal immunity in aged mice. In particular, a pneumococcal surface protein A-based nasal vaccine given with pFL and CpG ODN induced complete protection from S. pneumoniae infection. These results show that nasal delivery of a combined DNA adjuvant offers an attractive potential for protection against the pneumococcus in the elderly.

• 出版日期2015-2
• 单位河北医科大学