Normal values of quantitative T2 ' in a spontaneously hypertensive stroke prone rat stem at 3 T

作者：Jensen Kondering U^*; Boehm R; Hoecker J; Ruhe R; Brdon J; Ulmer S; Herdegen T; Jansen O

来源：European Journal of Radiology, 2012, 81(5): 985-987.

DOI：10.1016/j.ejrad.2011.02.011

• MRI
• Stroke
• Rats
• qT2*
• T2
• T2*
• Relaxation

Introduction: Regarding therapy and prognosis of acute ischemic stroke the identification of ischemic penumbra is pivotal. A promising candidate is BOLD-imaging using qT2'-maps. For valid interpretation of experimental studies in animals normal values for qT2' are needed. Normal values in humans at 1.5 T already exist. Normal values for cortical and subcortical structures in a spontaneously hypertensive stroke prone rat stem (SHR-SP) at a fieldstrength of 3 T are reported.
Materials and methods: 39 (20 males and 19 females) spontaneously hypertensive stroke prone (SHRSP) rats were examined in a 3 T scanner using a dedicated small animal coil. Mean weight was 144.1 +/- 8.2 g and mean age was 60.2 +/- 2.7 days. For the calculation of qT2' multiple echo T2w and T2*w images were acquired. ROIs were placed into deep and cortical grey matter in five different brain regions to obtain values for qT2', qT2 and qT2*.
Results: Mean qT2' for cortical grey matter was 74.76 +/- 33.27 ms and 67.73 +/- 17.86 ms for deep grey matter. The 99% confidence interval for cortical grey matter was 69.91-79.61 ms. For qT2 it was 79.02 +/- 2.9 ms and 70.45 +/- 1.89 ms, respectively. For qT2* it was 34.65 +/- 5.25 ms and 31.9 +/- 2.99 ms.
Conclusion: The values for qT2' presented here can serve as reference values for further studies examining the ischemic penumbra in a rat model.

• 出版日期2012-5