Anti-HIV protease triterpenoids from the acid hydrolysate of Panax ginseng

作者：Wei Ying; Ma Chao Mei; Hattori Masao^*

来源：Phytochemistry Letters, 2009, 2(2): 63-66.

DOI：10.1016/j.phytol.2008.12.001

• Panax ginseng
• Araliaceae
• Triterpenoid
• (20R)-20,25-Epoxy-dammaran-2-en-6 alpha,12 beta-diol
• (20R)-20,25-Epoxy-3-methyl-28-nordammaran-2-en-6 alpha,12 beta-diol
• Isodehydroprotopanaxatriol
• HIV-1 protease inhibitor

Three artificial triterpenoids, (20R)-20,25-epoxy-dammaran-2-en-6 alpha,12 beta-diol (1), (2OR)-20,25-epoxy-3-methyl-28-nordammaran-2-en-6 alpha,12 beta-diol (2) and isodehydroprotopanaxatriol (3), were isolated from an acidic hydrolysate of Panax ginseng C.A. Meyer, along with three known triterpenes, (20R)-panaxadiol (4),(20R)-panaxatriol (5) and oleanolic acid (6). Compounds 1-3 and 6 showed inhibitory activity against HIV-1 protease with IC(50) of 10.5, 10.3, 12.3 and 6.3 mu M, respectively. The results indicated that acid treatment of Ginseng extract could produce diverse structures with interesting bioactivity.

• 出版日期2009-4-29
• 单位贵州中医药大学