A Cell Culture (Vero)-Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses

作者：Ehrlich Hartmut J; Mueller Markus; Fritsch Sandor; Zeitlinger Markus; Berezuk Greg; Loew Baselli Alexandra; van der Velden Maikel V W; Poellabauer Eva Maria; Maritsch Friedrich; Pavlova Borislava G; Tambyah Paul A; Oh Helen M L; Montomoli Emanuele; Kistner Otfried; Barrett P Noel

来源：Journal of Infectious Diseases, 2009, 200(7): 1113-1118.

DOI：10.1086/605608

Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12-17 months after priming) with a 7.5-mu g dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic.

• 出版日期2009-10-1