A review of management strategies of malignant gliomas in the elderly population

作者：Kumthekar Priya U; Macrie Bryan D; Singh Simran K; Kaur Gurvinder; Chandler James P; Sejpal Samir V^*

来源：American Journal of Cancer Research, 2014, 4(5): 436-444.

• High grade glioma
• GBM
• MGMT
• malignant astrocytoma
• elderly patients

Glioblastoma Multiforme (GBM) is the most frequent primary malignant brain tumor in adults. It is an aggressive primary brain neoplasm, associated with a poor prognosis and median survival of less than 1 year. Approximately 50% of patients diagnosed with malignant gliomas in the United States are over the age of 65. Advancing age and poor performance status are two variables that have found to negatively affect prognosis. When compared to younger patients, not only is the treatment of elderly patients associated with decreased efficacy but also greater toxicity. As a result, elderly patients often receive less aggressive treatment and are excluded from clinical trials. There are many challenges in the treatment of elderly patients with GBM including increased surgical morbidity and mortality as well as increased toxicity to radiation and chemotherapy. As such, the optimal therapy remains unclear and controversial for the elderly malignant glioma population.

• 出版日期2014
• 单位西北大学