A DOX-loaded polymer micelle for effectively inhibiting cancer cells

作者：Feng, Huayang; Chu, Dandan; Li, Zhanrong; Guo, Zhihua; Jin, Lin; Fan, Bingbing^*; Zhang, Junjie; Li, Jingguo^*

来源：RSC Advances, 2018, 8(46): 25949-25954.

DOI：10.1039/c8ra04089c

• DRUG-DELIVERY
• CO-DELIVERY
• SIRNA DELIVERY
• PH
• DOXORUBICIN
• NANOPARTICLES
• CHEMOTHERAPY
• REDUCTION
• THERAPY
• COPOLYMER

A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. The synthetic process involves the ring-opening polymerization, carboxylation and amidation reactions, and the structures are characterized. The drug release test indicated that the micelles have the ability to control the release of drugs. The cell uptake results indicated that the DOX-loaded micelles could enter cancer cells easily, and the cytotoxicity and apoptosis test confirmed that DOX-loaded micelles have a strong killing effect on tumor cells, while the blank micelles do not have cytotoxicity. Therefore, the novel polymer micelles are a promising carrier for delivery of anticancer drugs to enhance cancer treatment.

• 出版日期2018
• 单位郑州大学