Necrotic enteritis in suggling piglets by interaction of Isospora suis and Clostridium perfringens

作者：Krueger Monika; Schroedl Wieland; Krueger Maxie; Schwarz Sandra; Mengel Heidrun; Daugschies Arwid; Swidsinski Alexander; Mundt Hans Christian; Westphahl Bernhardt

来源：Praktische Tierarzt, 2010, 91(9): 774-+.

• Isospora suis
• Clostridium perfringens type A
• type A (beta 2)
• type C
• necrotic enteritis
• treatment
• toltrazuril

This study tested the hypothesis that inoculation of six-hour-old newborn piglets naturally colonized with Clostridium (C.) perfringens with 1,000 Isospora (I.) suis oocysts promotes the development of necrotic enteritis (NE). In order to analyze whether it is possible to prevent or reduce NE by treating piglets metaphytactically twelve hours after I. suis inoculation with 20 mg toltrazuril/kg body weight (Baycox (R), Bayer Vital GmbH, D), all piglets (n = 31) produced by three sows from a pig farm with a history of C. perfringens infection were randomized into treated and untreated infection groups. These groups were compared with a non-infected control group (n = 14) of two sows. The impact of intestinal coccidial infection and anti-coccidial treatment on clinical status, faecal consistency, oocyst excretion, and microbial community structure in the faeces and gut compartments was evaluated by means of clinical and faecal investigations as well as culture-based and molecular (PCR, FISH) bacteriological techniques. Untreated animals developed diarrhoea accompanied by weight loss. Five untreated piglets (33.3 %) initially colonised with C. perfringens died. Three piglets (20 %) died with typical lesions between study day 8 and 14 from NE. None of the treated animals died although colonised with C. perfrirtgens. These results prove our working hypothesis.

• 出版日期2010-9-1