Associations Between Short-term Changes in Air Pollution and Correlates of Arterial Stiffness: The Veterans Affairs Normative Aging Study, 20072011

作者：Mehta Amar J^*; Zanobetti Antonella; Koutrakis Petros; Mittleman Murray A; Sparrow David; Vokonas Pantel; Schwartz Joel

来源：American Journal of Epidemiology, 2014, 179(2): 192-199.

DOI：10.1093/aje/kwt271

• air pollution
• particulate matter
• pulse wave analysis

We investigated associations between short-term exposure to air pollution and central augmentation index and augmentation pressure, correlates of arterial stiffness, in a cohort of elderly men in the Boston, Massachusetts, metropolitan area. This longitudinal analysis included 370 participants from the Veterans Affairs Normative Aging Study with up to 2 visits between 2007 and 2011 (n 445). Augmentation index (as ) and augmentation pressure (in mmHg) were measured at each visit by using radial artery applanation tonometry for pulse wave analysis and modeled in a mixed effects regression model as continuous functions of moving averages of air pollution exposures (over 4 hours and 1, 3, 7, and 14 days). The results suggest that short-term changes in air pollution were associated with augmentation index and augmentation pressure at several moving averages. Interquartile range (IQR) increases in 3-day average exposure to particles with aerodynamic diameter less than 2.5 m (3.6-g/m(3) IQR increase) and sulfate (1.4-g/m(3) IQR increase) and 1-day average exposure to particle number counts (8,741-counts/cm(3) IQR increase) were associated with augmentation index values that were 0.8 (95 confidence interval (CI): 0.2, 1.4), 0.6 (95 CI: 0.1, 1.2), and 1.7 (95 CI: 0.4, 2.9) higher, respectively. Overall, the findings were similar for augmentation pressure. The findings support the hypothesis that exposure to air pollution may affect vascular function.

• 出版日期2014-1-15