An unusual transmission event of Neisseria meningitidis serogroup W135 type 2a in a healthcare setting, England, 2012

作者：Puleston R^*; Beck C; Tahir M; Bardhan M; Charlemagne P; Alves C; Ladhani S; Watson C; Ramsay M; Kaczmarksi E; Borrow R; Gray S; Hadlington D; Weinbren M; Bhattacharjee D; Inglis N

来源：Eurosurveillance, 2012, 17(44): 5-7.

We report an outbreak of Neisseria meningitidis serogroup W135, associated with a transient transmission event between asymptomatic individuals in a health-care setting. Two elderly persons subsequently developed invasive meningococcal disease. The duration and type of close contact for those directly involved in the probable transmission incident would not have warranted chemoprophylaxis according to current guidelines. Meningococcal infection in older persons usually presents with pneumonia rather than meningitis or septicaemia with purpura.
We report a nosocomial outbreak of Neisseria meningitidis serogroup W135, phenotype 2a:P1.5, 2 associated with a transient transmission event between asymptomatic individuals in March 2012. Two elderly individuals admitted to the same hospital group (at different sites) presented within four days of each other with non-specific respiratory tract symptoms of infection. Initial microbiological analysis isolated N. meningitidis serogroup W135:2a:P1.5, 2 (porA genotype 5, 2, 36-2) from both patients' blood cultures. The identical microbiological phenotype/genotype of these isolates suggested an epidemiological link.

• 出版日期2012-11-1