The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V

作者：Knops Elena^*; Kemper Ina; Schuelter Eugen; Pfister Herbert; Kaiser Rolf; Verheyen Jens

来源：AIDS, 2010, 24(5): 779-781.

DOI：10.1097/QAD.0b013e328336784d

Recently, first-line lopinavir failure was observed due to protease mutation 76V. In the present study, we found 76V associated with protease mutation 46I and gag cleavage-site mutation 431V. Longitudinal analysis of patients failing protease inhibitor therapies demonstrated that 76V strictly occurs either together with 46I and/or 431V or in HIV isolates already harbouring one of both mutations. Therefore, all three mutations seem to cooperate in terms of protease inhibitor resistance.

• 出版日期2010-3-13