A novel "turn-on" fluorescence probe based on azoaniline-arylimidazole dyad for the detection of Cu2+

作者：Wang, Yongpeng; Liu, Shuzhi; Chen, Hongbiao^*; Liu, Yijiang^*; Li, Huaming

来源：Dyes and Pigments, 2017, 142: 293-299.

DOI：10.1016/j.dyepig.2017.03.051

• Fluorescence probe
• Azoaniline-arylimidazole dyad
• Fluorescence enhancement
• Oxidative cyclization
• Bioimaging

A novel fluorescence probe TPI-AD bearing azoaniline and arylimidazole moieties is conveniently synthesized for the detection of Cu2+. A "naked-eye" visible color change from colorless to lake-blue together with a 220-fold fluorescence enhancement can be achieved by Cu2+-catalyzed oxidative cyclization, which transforms the non-emissive TPI-AD into strongly fluorescence benzotriazole derivative (TPI-BTA). The TPI-AD probe can be applied for quantitative detection of Cu2+ with good linear relationship between its fluorescence intensity and Cu2+ concentration. Moreover, TPI-AD shows high selectivity over other common metal ions as well as excellent sensitivity with a detection limit of 14.4 nM. In addition, the fluorescence imaging of living cells MCF-7 reveals the potential application of TPI-AD in biological system.

• 出版日期2017-7
• 单位湘潭大学