Systemic oxidative stress, as measured by urinary allantoin and F-2-isoprostanes, is not increased in Down syndrome

作者：Tolun Adviye A; Scarbrough Peter M; Zhang Haoyue; McKillop Jane Ann; Wang Frances; Kishnani Priya S; Millington David S; Young Sarah P; Il'yasova Dora^*

来源：Annals of Epidemiology, 2012, 22(12): 892-894.

DOI：10.1016/j.annepidem.2012.09.005

• Down syndrome
• Biomarker
• Urine
• Tandem mass spectrometry

Purpose: Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2 alpha-III; these biomarkers have been previously validated in a clinical model of oxidative stress.
Methods: Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration.
Results: After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P = .04). The adjusted mean levels of 2,3-dinor-iPF2 alpha-III were similar in DS individuals and controls (P = .7).
Conclusions: Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.

• 出版日期2012-12