New azaphilones from Chaetomium globosum isolated from the built environment

作者：McMullin David R; Sumarah Mark W; Blackwell Barbara A; Miller J David^*

来源：Tetrahedron Letters, 2013, 54(6): 568-572.

DOI：10.1016/j.tetlet.2012.11.084

• Chaetomium globosum
• Azaphilone
• Chaetomugilin
• Chaetoviridin
• Isochromophilone

A strain of Chaetomium globosum (DAOM 240359) was isolated from an indoor air sample in Ottawa, Ontario, Canada. When fermented in liquid culture, this strain produced a number of known metabolites including chaetoglobosins A (6), C, and F (7), chaetomugilin D (5), chaetoviridin A (4), and three new nitrogenous azaphilones; 4%26apos;-epi-N-2-hydroxyethyl-azachaetoviridin A (1), N-2-butyric-azochaetoviridin E (2), and isochromophilone XIII (3). The structures were elucidated by spectroscopic analysis including; HRMS, 1D and 2D NMR, UV, and ORD. Compounds 2-7 were antimicrobial when tested using quantitative growth inhibition assays.

• 出版日期2013-2-6