A representative of the dominant human colonic Firmicutes, Roseburia faecis M72/1, forms a novel bacteriocin-like substance

作者：Hatziioanou Diane; Mayer Melinda J^*; Duncan Sylvia H; Flint Harry J; Narbad Arjan

来源：Anaerobe, 2013, 23: 5-8.

DOI：10.1016/j.anaerobe.2013.07.006

• Roseburia faecis
• Bacteriocin-like inhibitory substance (BLIS)
• Firmicutes anaerobe
• Gut microbiota
• Trypsin

During screening of human gut isolates in search of novel antimicrobials, the butyrate-producing strain Roseburia faecis M72/1 was found to produce an inhibitory substance active against Bacillus subtilis. Partial purification of the antimicrobial was achieved and activity found to be heat labile. Our findings suggest that R. faecis M72/1 produces a proteinaceous inhibitor whose production may be triggered by trypsin in the gastrointestinal tract.

• 出版日期2013-10