Naringin Protects Pancreatic beta-Cells Against Oxidative Stress-Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin-Deficient Diabetic Mice

作者：Lim Ye Jin; Kim Jung Ho; Pan Jeong Hoon; Kim Jae Kyeom; Park Tae Sik; Kim Young Jun; Lee Jin Hyup; Kim Jun Ho

来源：Molecular Nutrition & Food Research, 2018, 62(5): 1700810.

DOI：10.1002/mnfr.201700810

<jats:sec><jats:title>Scope</jats:title><jats:p>Oxidative stress has been suggested to play a central role in the pathogenesis of diabetes, as well as other metabolic disorders. Naringin, a major flavanone glycoside in citrus species, has been shown to display strong antioxidant potential in in vitro and in vivo models of oxidative stress; however, the underlying protective mechanisms in diabetes are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>To study the protective effects and molecular mechanisms of naringin in preventing islet dysfunction and diabetes, we examined glucose homeostasis, β‐cell apoptosis, and inflammatory response in insulin‐deficient diabetic mice exposed to acute oxidative stress with streptozotocin (STZ). Naringin dose‐dependently ameliorated hyperglycemia and islet dysfunction in insulin‐deficient diabetic mice. Naringin counteracted STZ‐induced β‐cell apoptosis by inhibiting both the intrinsic (mitochondria‐mediated) and extrinsic (death receptor‐mediated) pathways. Furthermore, these protective effects were associated with suppression of DNA damage response and nuclear factor–kappa B– and mitogen–activated protein kinase–mediated signaling pathways, as well as reduction of reactive oxygen species accumulation and pro‐inflammatory cytokine production in the pancreas.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Taken together, our study provides insights into the underlying mechanisms through which naringin protects the pancreatic β‐cells against oxidative stress‐induced apoptosis.</jats:p></jats:sec>

• 出版日期2018-3