Estimating drug/plasma concentration levels by applying neural networks to pharmacokinetic data sets

作者：Tolle KM^*; Chen HC; Chow HH

来源：Decision Support Systems, 2000, 30(2): 139-151.

DOI：10.1016/S0167-9236(00)00094-4

• artificial neural networks
• medical applications
• medical user interfaces
• pharmaceutical estimation applications
• pharmacokinetic prediction

Predicting blood concentration levels of pharmaceutical agents in human subjects can be made difficult by missing data and variability within and between human subjects. Biometricians use a variety of software tools to analyze pharmacokinetic information in order to conduct research about a pharmaceutical agent. This paper is the comparison between using a feedforward backpropagation neural network to predict blood serum concentration levels of the drug tobramycin in pediatric cystic fibrosis and hematologic-oncologic disorder patients with the most commonly used software for analysis of pharmacokinetics, NONMEM(R). Mean squared standard error is used to establish the comparability of the two estimation methods. The motivation for this research is the desire to provide clinicians and pharmaceutical researchers a cost effective, user friendly, and timely analysis tool for effectively predicting blood concentration ranges in human subjects.

• 出版日期2000-12-27