科研之友
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摘要
Determine the dose-dependent effects of dexmedetomidine on anesthetic requirements and cardiopulmonary functions during one-lung ventilation in patients undergoing lobectomy. Sixty patients participated into the study. They wererandomized into four study groups and received placebo (normal saline), low (0.3 mu g/kg/hr), intermediate (0.5 mu g/kg/hr), or high (0.7 mu g/kg/hr) dose of dexmedetomidine. Amount of anesthetic and hemodynamic agents used were documented. Bispectral index, heart rate, mean arterial blood pressure, arterial oxygen partial pressure, and intrapulmonary shunt were recorded at 0 and 10, 20, 30, 40, 50, 60 minutes after dexmedetomidine infusion, and at the end of the operations. No decreased requirements for propofol or sufentanil during anesthesia were observed. High dose of dexmedetomidine (0.7 mu g/kg/hr) group required more atropine to maintain hemodynamic stability. Although there were no statistically significant differences in arterial blood gas analyses, patients received intermediate dose of dexmedetomidine (0.5 mu g/kg/hr) showed persistent higher values on PaO2. During one-lung ventilation for lobectomy, dexmedetomidine did not decrease the requirements for propofol and sufentanil administration. Intermediate dose of dexmedetomidine (0.5 mu g/kg/hr) might improve oxygenation with no adverse effects on hemodynamic stability. High dose of dexmedetomidine (0.7 mu g/kg/hr) required additional hemodynamic stabilizing agent, with no apparent benefit on oxygenation. Future studies with a large sample size are warranted.
