MTOR regulates autophagic flux in the glomerulus

作者：Cina Davide P; Onay Tuncer; Paltoo Aarti; Li Chengjin; Maezawa Yoshiro; De Arteaga Javier; Jurisicova Andrea; Quaggin Susan E^*

来源：Autophagy, 2012, 8(4): 696-698.

DOI：10.4161/auto.19386

• MTOR
• autophagy
• podocyte
• proteinuria
• rapamycin
• autolysosomal reformation

Sirolimus (rapamycin), an inhibitor of the mechanistic target of rapamycin (MTOR), was originally proposed as an immunosuppressant to prevent rejection of solid organ transplants. There were expectations that MTOR inhibitors would replace nephrotoxic calcineurin inhibitors (CNIs). Despite its potential advantages, evidence that sirolimus causes de novo or worsening proteinuria is unequivocal. Given the well-recognized proteinuric effect of MTOR inhibitors, we were interested in understanding its role in maintaining the glomerular filtration barrier. To investigate this in vivo, we developed a mouse model with a podocyte selective deletion of the Mtor gene (Mtor pod-KO).

• 出版日期2012-4