Multi-institutional retrospective analysis of learning curves on dosimetry and operation time before and after introduction of intraoperatively built custom-linked seeds in prostate brachytherapy

作者：Ishiyama Hiromichi^*; Satoh Takefumi; Yorozu Atsunori; Saito Shiro; Kataoka Masaaki; Hashine Katsuyoshi; Nakamura Ryuji; Tanji Susumu; Masui Koji; Okihara Koji; Ohashi Toshio; Momma Tetsuo; Aoki Manabu; Miki Kenta; Kato Masako; Morita Masashi; Katayama Norihisa; Nasu Yasutomo; Kawanaka Takashi; Fukumori Tomoharu; Ito Fumitaka; Shiroki Ryoichi; Baba Yuji; Inadome Akito; Yoshioka Yasuo; Takayama Hitoshi; Hayakawa Kazushige

来源：Journal of Radiation Research, 2016, 57(1): 68-74.

DOI：10.1093/jrr/rrv065

• prostate cancer
• brachytherapy
• low dose rate
• I-125
• intraoperatively built custom-linked seed
• loose seed

This multi-institutional retrospective analysis examined learning curves for dosimetric parameters and operation time after introduction of intraoperatively built custom-linked (IBCL) seeds. Data from consecutive patients treated with seed implantation before and after introduction of IBCL seeds (loose seed, n = 428; IBCL seed, n = 426) were collected from 13 centers. Dose-volume histogram parameters, operation times, and seed migration rates were compared before and after introduction of IBCL seeds. At the 1-month CT analysis, no significant differences were seen in dose to 90% of prostate volume between before and after IBCL seed introduction. No learning curve for dosimetry was seen. Prostate and rectal volume receiving at least 150% of prescription dose (V150 and RV150) were higher in the loose-seed group than in the IBCL-seed group. Operation time was extended by up to 10 min when IBCL seeds were used, although there was a short learning curve of about five patients. The percentage of patients with seed migration in the IBCL-seed group was one-tenth that in the loose-seed group. Our study revealed no dosimetric demerits, no learning curve for dosimetry, and a slightly extended operation time for IBCL seeds. A significant reduction in the rate of seed migration was identified in the IBCL-seed group.

• 出版日期2016-1