Adiponectin and sE-selectin Concentrations in Relation to Inflammation in Obese Type 2 Diabetic Patients With Coronary Heart Disease

作者：El Mesallamy Hala O; Hamdy Nadia M^*; Salman Tarek M; Ibrahim Sherine M

来源：Angiology, 2012, 63(2): 96-102.

DOI：10.1177/0003319711408587

• Obesity
• type 2 diabetes mellitus
• coronary heart diseases
• adiponectin
• sE-selectin
• interleukin 1 beta
• monocyte chemotactic protein 1

Adipose tissue can release proinflammatory mediators, namely C-reactive protein (CRP), interleukin 1 beta (IL-1 beta), and monocyte chemotactic protein 1 (MCP-1), contributing to vascular injury and insulin resistance (IR). Other mediators namely, adiponectin and nitric oxide (NO) are protective. We enrolled type 2 diabetes mellitus (T2DM) obese male patients without coronary heart disease ([CHD] group II, n = 25) and T2DM obese patients with CHD (group III, n = 25). They were compared with 20 age- and body mass index (BMI)-matched nondiabetic control males (group I). Fasting blood glucose (FBG), glycated hemoglobin (HbA(1c)%), lipids, insulin, malondialdehyde ([MDA]; lipid peroxidation product), NO, high-sensitivity CRP (hsCRP), IL-1 beta, MCP-1, adiponectin as well as sE-selectin concentration were significantly different in patients with T2DM and CHD compared with patients without CHD and nondiabetic controls (P = .01). There was a significant negative correlation between adiponectin and E-selectin (P = .0001). Adipose tissue in T2DM obese patients may contribute to the pathogenesis of CHD.

• 出版日期2012-2