A Double-Blind Randomized Study Evaluating the Effect of Intra-Alveolar Chlorhexidine Gel on Alveolar Osteitis After Removal of Mandibular Third Molars

作者：Freudenthal Nelly^*; Sternudd Mika; Jansson Leif; Wannfors Karin

来源：Journal of Oral and Maxillofacial Surgery, 2015, 73(4): 600-605.

DOI：10.1016/j.joms.2014.08.035

Purpose: The main purpose of the present investigation was to determine whether intra-alveolar chlorhexidine (CHX) gel is an effective preventative treatment for alveolar osteitis (AO), as has been strongly suggested by previous investigators. Another goal was to evaluate whether there is a correlation between the use of analgesics during the postoperative week and the development of AO, a correlation that could be a supplement to the commonly used diagnostic criteria for AO.
Materials and Methods: A double-blinded randomized study was performed to assess whether intra-alveolar administration of CHX decreases AO. To achieve this objective, the extraction and postoperative course of 100 impacted mandibular third molars were studied. Ninety-seven percent of teeth operated on had a diagnosed pathology. The extraction alveoli were treated with CHX or placebo. The intake of analgesics was recorded for 7 days after the operation.
Results: Statistically important differences in AO between the control and experimental groups were not found. The intake of analgesics reflected the occurrence of AO with a high degree of importance.
Conclusion: The present study did not verify that application of CHX gel improves healing after removal of impacted third molars. The patients' postoperative analgesic intake reflected the development of AO.

• 出版日期2015-4