Analogues of the Epoxy Resin Monomer Diglycidyl Ether of Article Bisphenol F: Effects on Contact Allergenic Potency and Cytotoxicity

作者：O' Boyle Niamh M; Delaine Tamara; Luthman Kristina; Natsch Andreas; Karlberg Ann Therese

来源：Chemical Research in Toxicology, 2012, 25(11): 2469-2478.

DOI：10.1021/tx300305k

Diglycidyl ethers of bisphenol A (DGEBA) and bisphenol F (DGEBF) are widely used as components in epoxy resin thermosetting products. They are known to cause occupational and nonoccupational allergic contact dermatitis. The aim of this study is. to investigate analogues of DGEBF with regard to contact allergy and cytotoxicity. A comprehensive knowledge of the structural features that contribute to the allergenic and cytotoxic effects of DGEBF will guide the development of future novel epoxy resin systems with reduced health hazards for those coming into contact with them. It was found that the allergenic effects of DGEBF were dependent on its terminal epoxide groups. In contrast, it was found that the cytotoxicity in monolayer cell culture was dependent not only on the presence of epoxide groups but also on other structural features.

• 出版日期2012-11