A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones

作者：Ramesh Chintakunta; Lei Po Min; Kavala Veerababurao; Kuo Chun Wei; Yao Ching Fa^*

来源：Molecules, 2012, 17(5): 5081-5094.

DOI：10.3390/molecules17055081

• one-pot procedure
• Morita-Baylis-Hillman adducts
• quinolines
• reductive cyclization
• Fe/AcOH

A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3-(phenylthiomethyl)quinolines were transformed into 2-methyl-3-(phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation.

• 出版日期2012-5