科研之友
微信
新浪微博
Facebook
分享链接
摘要
Non-natural amino acids can be used to expand the protein sequence space significantly beyond the limits set by nature. Expanding the protein sequence space opens a new door to engineering and chemically modifying proteins. Reassigning codons to non-natural amino acids as well as engineering protein translational machinery is required to incorporate non-natural amino acids into a single or multiple sites of a target protein in cells. Non-natural amino acid incorporation holds a great promise in substantially improving protein intrinsic properties and providing new orthogonal chemistries to proteins for bioconjugation.
- 出版日期2013-6-25
