The role of the human leukocyte antigen system in retinopathy of prematurity: a pilot study

作者：Flor de Lima Filipa; Rocha Gustavo^*; Proenca Elisa; Tafulo Sandra; Freitas Fatima; Guimaraes Hercelia

来源：Acta Paediatrica, 2013, 102(12): 1150-1153.

DOI：10.1111/apa.12410

• Genetics
• Human leukocyte antigen alleles
• Retinopathy of prematurity

AimTo assess the association between the human leukocyte antigen system and retinopathy of prematurity. %26lt;br%26gt;MethodsNeonates of %26lt;32weeks of gestational age, born at two level III neonatal intensive care units from January 2000 to December 2001 and from January 2006 to June 2009, were included in the study. Demographic and clinical data were recorded, and retinopathy was classified according to the International Classification. Epithelial cells were collected from the oral cavity and the HLA were studied using the PCR/SSO method. Univariate and multivariate analyses were performed using SPSS (R) v.18. %26lt;br%26gt;ResultsWe evaluated 156 neonates, including 82 (52.6%) males. Median gestational age was 29 (23-31) weeks, and median birth weight was 1030 (525-1935) grams. Seventy (44.9%) of the neonates developed retinopathy. Alleles HLA-B*38, HLA-Cw*12, HLA-DRB1*09, HLA-DRB1*14 (univariate analysis) and HLA-A*68 and HLA-Cw*12 were associated to retinopathy (multivariate analysis). %26lt;br%26gt;ConclusionThe results suggest that the HLA system may be associated with the development of retinopathy of prematurity. A large-scale population-based study should be performed to clarify this association.

• 出版日期2013-12