Applications of computational models to better understand microvascular remodelling: a focus on biomechanical integration across scales

作者：Murfee Walter L^*; Sweat Richard S; Tsubota Ken ichi; Mac Gabhann Feilim; Khismatullin Damir; Peirce Shayn M

来源：Interface Focus, 2015, 5(2): UNSP 20140077.

DOI：10.1098/rsfs.2014.0077

• microcirculation
• angiogenesis
• agent-based model
• computational fluid dynamics
• hypertension
• multiscale computational model

Microvascular network remodelling is a common denominator for multiple pathologies and involves both angiogenesis, defined as the sprouting of new capillaries, and network patterning associated with the organization and connectivity of existing vessels. Much of what we know about microvascular remodelling at the network, cellular and molecular scales has been derived from reductionist biological experiments, yet what happens when the experiments provide incomplete (or only qualitative) information? This review will emphasize the value of applying computational approaches to advance our understanding of the underlying mechanisms and effects of microvascular remodelling. Examples of individual computational models applied to each of the scales will highlight the potential of answering specific questions that cannot be answered using typical biological experimentation alone. Looking into the future, we will also identify the needs and challenges associated with integrating computational models across scales.

• 出版日期2015-4-6