Drug release property of a pH-responsive double-hydrophilic hyperbranched graft copolymer

作者：Sun XiaoYi; Zhou YongFeng^*; Yan DeYue

来源：Science in China Series B-Chemistry, 2009, 52(10): 1703-1710.

DOI：10.1007/s11426-009-0227-4

• hyperbranched polymers
• double-hydrophilic copolymer
• polyglycerol
• ATRP
• drug delivery

In this paper, we report the synthesis and self-assembly of double-hydrophilic hyperbranched graft copolymers of HPG-g-PDMAEMA, which consist of a hyperbranched polyglycerol (HPG) core and several grafted poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) arms. HPG was synthesized by cationic polymerization. Then HPG-Br macroinitiator was obtained by esterification of HPG with 2-bromoisobutyryl bromide, which was subsequently used in the preparation of HPG-g-PDMAEMA graft copolymers through atom transfer radical polymerization (ATRP) of DMAEMA monomers. The molecular structures were studied by H-1 NMR and GPC. The pyrene-based fluorescent probe method, H-1 NMR and DLS were used to study the self-assembly behavior of HPG-g-PDMAEMA. The drug loading and pH-responsive release properties of HPG-g-PDMAEMA were also investigated by using coumarin 102 as a model drug. The results show that the HPG-g-PDMAEMA micelles can continuously release and re-encapsulate coumarin 102 as the pH continuously changes from 11.5 to 2.5; however, this process is not totally reversible.

• 出版日期2009-10
• 单位上海交通大学