Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype

作者:Tsuji Brian T*; von Eiff Christof; Kelchlin Pamela A; Forrest Alan; Smith Patrick F
来源:Antimicrobial Agents and Chemotherapy, 2008, 52(4): 1533-1537.
DOI:10.1128/AAC.01254-07

摘要

The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.