The utility of urinary myo-inositol as a marker of glucose intolerance

作者：Ikezaki Hiroaki; Furusyo Norihiro^*; Okada Kyoko; Ihara Takeshi; Hayashi Takeo; Ogawa Eiichi; Kainuma Mosaburo; Murata Masayuki; Hayashi Jun

来源：Diabetes Research and Clinical Practice, 2014, 103(1): 88-96.

DOI：10.1016/j.diabres.2013.11.018

• Myo-inositol
• Diabetes
• Oral glucose tolerance test

Objective: The most common screening tests for glucose intolerance are fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful. We evaluated UMI as a screening tool for glucose intolerance.
Design and methods: A cross-sectional, community-based population study of 1057 Japanese residents. 173 with an FPG level between 5.5 and 6.9 mmol/L and an HbA1c under 6.5% had an oral glucose tolerance test. We measured UMI level before (fasting UMI) and 2 h after (2 h-UMI) glucose ingestion. Delta-UMI was defined as the difference between fasting UMI and 2 h-UMI.
Results: Delta-UMI, 2 h-UMI and HbA1c levels significantly increased as glucose intolerance worsened. Delta-UMI level was significantly positively correlated with 2 h-UMI level (r = 0.896, p < 0.001). Using cutoff levels from receiver operating characteristic (ROC) analyses, the sensitivity of Delta-UMI (82.1%) and 2 h-UMI (79.3%) were higher than that of HbA1c (48.3%). The area under the ROC curve values for Delta-UMI (0.903) and 2 h-UMI (0.891) were higher than that for HbA1c (0.785).
Conclusions: 2 h-UMI is useful as a non-invasive screening of glucose intolerance.

• 出版日期2014-1